diff --git a/packages/angular_devkit/build_angular/src/tools/babel/plugins/pure-toplevel-functions.ts b/packages/angular_devkit/build_angular/src/tools/babel/plugins/pure-toplevel-functions.ts
index 08947506049f..75cbdd86ecdf 100644
--- a/packages/angular_devkit/build_angular/src/tools/babel/plugins/pure-toplevel-functions.ts
+++ b/packages/angular_devkit/build_angular/src/tools/babel/plugins/pure-toplevel-functions.ts
@@ -71,6 +71,13 @@ export default function (): PluginObject {
           return;
         }
 
+        // Do not annotate standalone expression statements.
+        // Standalone expression statements are executed solely for their side effects;
+        // marking them pure causes minifiers to drop them as dead code.
+        if (path.parentPath.isExpressionStatement()) {
+          return;
+        }
+
         const callee = path.get('callee');
         if (
           (callee.isFunctionExpression() || callee.isArrowFunctionExpression()) &&
@@ -96,6 +103,13 @@ export default function (): PluginObject {
           return;
         }
 
+        // Do not annotate standalone expression statements.
+        // Standalone expression statements are executed solely for their side effects;
+        // marking them pure causes minifiers to drop them as dead code.
+        if (path.parentPath.isExpressionStatement()) {
+          return;
+        }
+
         const { topLevelSafeMode = false } = state.opts;
 
         if (!topLevelSafeMode) {
diff --git a/packages/angular_devkit/build_angular/src/tools/babel/plugins/pure-toplevel-functions_spec.ts b/packages/angular_devkit/build_angular/src/tools/babel/plugins/pure-toplevel-functions_spec.ts
index c9d7eafd4aee..f3df13b1cca9 100644
--- a/packages/angular_devkit/build_angular/src/tools/babel/plugins/pure-toplevel-functions_spec.ts
+++ b/packages/angular_devkit/build_angular/src/tools/babel/plugins/pure-toplevel-functions_spec.ts
@@ -154,6 +154,28 @@ describe('pure-toplevel-functions Babel plugin', () => {
     `),
   );
 
+  it('does not annotate top-level call expression statements', testCaseNoChange('someCall();'));
+
+  it(
+    'does not annotate top-level IIFE expression statements',
+    testCaseNoChange(`
+      (() => {
+        _defineProperty(_Injector, 'ɵprov', ɵɵdefineInjectable({ token: _Injector }));
+        _defineProperty(_Injector, '__NG_ELEMENT_ID__', -1);
+      })();
+    `),
+  );
+
+  it(
+    'does not annotate top-level static block helper calls',
+    testCaseNoChange(`
+      _staticBlock();
+      _staticBlock2();
+    `),
+  );
+
+  it('does not annotate top-level new expression statements', testCaseNoChange('new SomeClass();'));
+
   describe('topLevelSafeMode: true', () => {
     it(
       'annotates top-level `new InjectionToken` expressions',